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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEATR1
All Species:
18.79
Human Site:
T553
Identified Species:
31.79
UniProt:
Q9H583
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H583
NP_060542.4
2144
242370
T553
E
H
F
S
S
E
V
T
I
S
N
L
L
N
L
Chimpanzee
Pan troglodytes
XP_001156974
2144
242420
T553
E
H
F
S
S
E
V
T
I
S
N
L
L
T
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536334
2141
242568
T553
Q
H
F
S
S
E
V
T
V
S
N
L
L
N
L
Cat
Felis silvestris
Mouse
Mus musculus
NP_659084
2143
242053
T553
Q
H
F
G
V
E
E
T
V
S
S
L
L
N
L
Rat
Rattus norvegicus
NP_001101888
2143
241191
T553
Q
H
F
G
V
E
E
T
V
S
N
I
L
N
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422958
2155
244590
V553
K
Q
V
N
P
E
V
V
V
S
S
L
L
S
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q7SY48
2159
242032
T551
G
L
M
D
V
E
D
T
V
S
S
L
I
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM75
2096
237201
P562
A
E
M
L
G
P
L
P
L
A
Q
T
L
C
H
Honey Bee
Apis mellifera
XP_393800
2028
231830
I531
T
V
L
L
S
A
D
I
L
I
D
E
L
K
I
Nematode Worm
Caenorhab. elegans
Q23495
1650
185210
F219
E
I
K
H
P
I
L
F
N
F
H
A
K
L
L
Sea Urchin
Strong. purpuratus
XP_794611
1635
181917
V204
I
K
A
H
K
K
T
V
L
P
G
G
S
P
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8Z4
2001
224001
K532
Q
A
A
L
S
F
D
K
L
P
N
I
I
T
S
Baker's Yeast
Sacchar. cerevisiae
P42945
1769
200063
K338
S
I
L
T
F
L
D
K
E
D
K
P
V
C
D
Red Bread Mold
Neurospora crassa
Q7RZM8
1788
196873
A357
D
K
L
A
N
G
L
A
L
A
L
V
D
R
L
Conservation
Percent
Protein Identity:
100
99.5
N.A.
89.7
N.A.
83.8
84.9
N.A.
N.A.
65.5
N.A.
54.5
N.A.
28.6
30.5
21.1
24.4
Protein Similarity:
100
99.8
N.A.
95
N.A.
92.1
92.7
N.A.
N.A.
80.5
N.A.
73
N.A.
49.4
50.8
38.9
43.2
P-Site Identity:
100
93.3
N.A.
86.6
N.A.
60
60
N.A.
N.A.
33.3
N.A.
33.3
N.A.
6.6
13.3
13.3
0
P-Site Similarity:
100
93.3
N.A.
100
N.A.
80
80
N.A.
N.A.
73.3
N.A.
60
N.A.
26.6
33.3
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.4
21.2
23
Protein Similarity:
N.A.
N.A.
N.A.
43.4
40.2
42.2
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
40
13.3
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
15
8
0
8
0
8
0
15
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% C
% Asp:
8
0
0
8
0
0
29
0
0
8
8
0
8
0
8
% D
% Glu:
22
8
0
0
0
50
15
0
8
0
0
8
0
0
0
% E
% Phe:
0
0
36
0
8
8
0
8
0
8
0
0
0
0
0
% F
% Gly:
8
0
0
15
8
8
0
0
0
0
8
8
0
0
0
% G
% His:
0
36
0
15
0
0
0
0
0
0
8
0
0
0
8
% H
% Ile:
8
15
0
0
0
8
0
8
15
8
0
15
15
0
15
% I
% Lys:
8
15
8
0
8
8
0
15
0
0
8
0
8
8
0
% K
% Leu:
0
8
22
22
0
8
22
0
36
0
8
43
58
8
58
% L
% Met:
0
0
15
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
8
0
0
0
8
0
36
0
0
29
8
% N
% Pro:
0
0
0
0
15
8
0
8
0
15
0
8
0
8
0
% P
% Gln:
29
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
8
0
0
22
36
0
0
0
0
50
22
0
8
15
8
% S
% Thr:
8
0
0
8
0
0
8
43
0
0
0
8
0
15
0
% T
% Val:
0
8
8
0
22
0
29
15
36
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _